Armed with a new Federation warship, the crew travels to the Gamma Quadrant on a mission to seek out and make contact with the leaders of the Dominion.
Sisko and the station's crew face the end of their work on DS9 when the Federation negotiates an uneasy peace with the Dominion. Odo explores his origins after finally making contact with his people.
Kira's efforts to uncover a lost week from her past leads her to a Cardassian family, who claims that she is an undercover operative of the Obsidian Order.
Jadzia falls in love with a man from a planet that periodically shifts between the Gamma Quadrant and a non-corporeal dimension, and hopes to stabilize the planet.
Thomas Riker, a twin of the Enterprise first officer created in a transporter accident, poses as his Starfleet double to steal the Defiant, using the warship to invade the Cardassian DMZ.
Station personnel experience amorous feelings for the most unlikely of people during a Bajoran festival. Miles and Keiko's relationship is put to the test by their extended separation.
A transporter accident sends Sisko, Bashir, and Dax to the twenty-first century, where San Francisco is fragmented by "sanctuary" zones where the poor are locked away from society -- and on the eve of a famous riot that will change the course of history.
Trapped with Bashir and Dax in 2024 San Francisco, Sisko assumes the identity of Gabriel Bell in an effort to save the hostages in a tense stand-off between the Sanctuary districts and the government, and put history back on track.
Odo and Kira find themselves trapped on a barren moon while chasing a Maquis terrorist, and Kira is trapped in an expanding crystalline structure. Nog asks for Sisko's support in applying to Starfleet.
Commander Sisko joins a Cardassian science team in establishing a communications relay in the Gamma Quadrant, despite a Bajoran prophecy warning that it will destroy the wormhole.
Quark tries to get to the bottom of Grand Nagus Zek's sudden personality change when he rewrites the Rules of Acquisition and establishes a charity fund.
Chief O'Brien finds himself jumping ahead five hours into his future, giving him a chance to prevent his own death -- and the destruction of the station.
Doctor Bashir is assaulted by an alien, and wakes up to find himself trapped inside his own mind, where the station is seriously damaged and almost completely abandoned.
Sisko constructs an ancient Bajoran space sailing ship to try and prove that the ancient Bajorans could have reached Cardassia, as their myth says. Doctor Bashir has to face the only person who beat him at the academy.
Quark and Rom return home when their mother is charged with the crime of earning profit as a female. Jake attempts to set up his dad with a freighter captain.
Jadzia faces each of her symbiont's previous hosts, with each of her friends volunteering to serve as temporary hosts to their consciences. But when Kerzon joins with Odo, he doesn't want to go back.
Newly-promoted Captain Sisko leads an investigation of a coup among a Federation neighbor, only to find that a Changeling saboteur has stowed away on the Defiant and is trying to start a war in the Alpha Quadrant.