Dylan takes Harper on a mysterious quest to locate the pieces of an ancient relic, but the two find themselves on the run when Dylan is framed for murder.
The Andromeda crew discover that a group of refugees they've taken on board are mentally insane -- and that an evil scientist may be hiding among them.
Andromeda takes on Beka's Uncle Sid -- who is running for a top government office in the new Commonwealth -- as a passenger after an attempt on his life, and the crew must discover which of his many enemies is trying to kill him.
When the Maru's slip engines are destroyed, the crew is picked up by an ancient Earth vessel -- which is incapable of slipstream travel and takes decades to travel between the stars.
After defeating Captain Hunt and being frozen in time for 300 years, Geheris Rhade assumes command of the Andromeda and sets about reshaping the universe.
The crew of the Andromeda lead a Commonwealth fleet in battle with the powerful Pyrians over a disputed planet, and Dylan learns that the outcome may have galactic consequences.