Now fugitives with limited resources and few allies, Coulson and his team engineer a daring raid on a high-security government facility that houses the advanced technology once held by S.H.I.E.L.D. But their enemy is a man who can change his body to match any material he touches.
After one of their mercenary associates is captured, the team worries that their operation could be compromised. May tracks the dangerous Creel -- who is experiencing problems with his ability -- and Fitz struggles with his inability to help retro-engineer a cloaking device.
With a new job working for the enemy Jemma learns that Hydra is attempting to recruit Donnie Gill, the young man with dangerous freezing abilities. While Coulson's team races to reach Donnie first, a Hydra operative attempts to brainwash a captured S.H.I.E.L.D. agent.
Agents Coulson and May go under cover at a high-society party to steal a painting that has a mysterious connection to Coulson's ailment. But the arrival of General Talbot complicates their mission, and calls the General's loyalties into question.
When Hydra uncovers the presence of a mole in their ranks, Jemma comes under scrutiny from their ruthless security chief, Bobbi Morse. Under pressure from Skye's mysterious father, Raina reaches out to Coulson in an attempt to force a family reunion.
Hydra attacks the United Nations posing as S.H.I.E.L.D., turning the world against the team. While May, Hunter, and Bobbi meet with a weapons dealer, Skye turns to Ward for help with his Senator brother.
Coulson puts his sanity on the line to locate a former TAHITI patient, who is tracking others like him in order to solve the mystery of the alien glyphs. Meanwhile May's team catches up with an elusive Ward.
The team discovers Dr. Whitehall's long history with Hydra, and Coulson leads a dangerous mission to secure a tool to locate the ancient city. While Bobbi interrogates Sunil Bakshi, Ward kidnaps his Senator brother to force him to admit his fault in a personal tragedy.
S.H.I.E.L.D. takes Raina into protective custody after Hydra tries to grab her -- led by Agent May's evil twin. Coulson leads a team to enter the ancient city, but get more than they bargained for.
When Skye finally meets her father face-to-face, he reveals what he believes is her destiny -- beginning with what waits below the surface in the ancient temple. Coulson's forces assault Whitehall's facility, and Fitz and Simmons hatch a plan to destroy the underground tunnels.
Rayna and Skye both struggle with their transformations, with Skye fearing her friends will turn against her. Meanwhile, Coulson uses a Hydra asset to strike at the head of the shadowy organization, and the team struggles with losing one of their own.
After Lady Sif turns up on Earth with her memory erased, Coulson and the team discover that she has been pursuing a Kree operative in Peru. Bobbi and Mac reach a decision that will have consequences for Hunter.
While Skye is evaluated by Agent May's psychiatrist ex-husband, Skye's father assembles a team of super-powered criminals in order to lure Coulson into a trap.
Ward and Agent 33 embark on a personal mission. Hunter finds himself in hot water after discovering Mack and Bobbi's secret, putting him face-to-face with the man targeting Agent Coulson.
After Coulson’s team discover that two of their own have loyalties to someone else, they find themselves under siege by another group calling themselves S.H.I.E.L.D. Elsewhere, a visitor helps Skye begin to see her new potential.
While Coulson and Hunter find a place to lay low, Gonzalez tries to convince Fitz and Simmons to help him crack their former leader's secret. Skye finds herself at a safe-haven for those with powers, where she meets a man assigned to help her with her transition.
Skye continues her training with Jiaying, and gains new insight into the secret community of meta-humans. May has to choose sides when evidence against Coulson mounts, pressing her to recall the fateful mission in Bahrain that made her who she is today.
Coulson forges an alliance with Grant Ward in order to get at one of Hydra's top brass. Skye intervenes when she learns that Cal is being removed from the community, leading to a strange father-daughter trip to Milwaukee.
Coulson convinces Gonzales to back a mission to infiltrate a Hydra facility and rescue Mike and Lincoln, who are being subjected to experiments by a scientist wanting to create and control powered people. Raina realizes the extent of her true powers, and Jemma hatches her own plan against Grant Ward.
After the Inhumans discover that S.H.I.E.L.D. possesses an artifact that is connected to a prophecy of their doom, Skye finds herself caught between both worlds. Coulson reveals the secret of Theta Project to his new allies.
Skye's loyalties are tested after Jiaying and the Inhumans declare war against S.H.I.E.L.D. Bobbi finds herself at the mercy of Ward and Agent 33, and Coulson suspects that Cal is being used against them as a Trojan Horse.
The true depth of Jiaying's plan is revealed when she uses the Terrigen crystals on her enemies, and the team fights to take the carrier back from the Inhumans. May and Hunter attempt to rescue Bobbi, unaware that they are walking into a trap -- and Skye is forced into a decisive confrontation with her mother.
