Aidan tries to direct the Boston vampire community, but is tormented by a figure from his past. Sally must face the consequences of missing her door, and Josh searches for a cure for his condition.
Josh finds himself trapped within his wolf, Sally tries to put her new powers to use, and a new boss in the vampire community makes Aidan's life more complicated.
A vampire and a werewolf discover they have a ghost as their new flatmate, and struggle to live normal lives -- while the local vampire community works to quietly increase its numbers.
Mitchell struggles to control the vampire community, while Annie looks for a new purpose in "life." George and Nina's relationship is affected by what has happened to her, and a secretive group begins experimenting on werewolves -- and keeping tabs on the housemates.
While Mitchell copes with his recent transgression, he and Annie continue to grow closer. The housemates discover a family of werewolves trying to stay under the radar.
After losing those closest to them, the housemates must prepare for a new onslaught from the vampire community and protect a child who may be the savior of them all.