The death of a mysterious woman in Chicago links eight strangers from all over the world, including a Chicago cop, a lesbian in San Francisco, a Latino film star, a safe cracker, an Indian bride-to-be, and a London DJ who is looking for more out of life.
Nomi receives devastating news after she falls unconscious during the pride march, while Kala's wedding to a man she doesn't love draws near. Things get complicated for Lito when he must fend off his co-star's advances, and Will is confronted by the mysterious Persian man.
Capheus finds himself in the middle of a desperate and dangerous situation after securing medication for his ailing mother, while Lito agrees to help Daniela with a personal problem. Riley seeks out an old friend, and Sun finds an outlet for her frustration.
Wolfgang and Felix attempt to sell their stolen gems, while Sun confronts her father about corruption inside the family company. Capheus receives an offer he cannot refuse, and Kala is told that her fiance may not be who she thought. Another encounter with Jonas convinces Will that he must help Nomi escape from the hospital.
The senseates' bonds grow stronger as they see one another more clearly and frequently. As Lito struggles on set with emotions that are not his own, Capheus discovers what he is capable of after his package is stolen. Nomi and Amanita learn that their place is being watched, and the day of Kala's wedding arrives.
Riley's life is in danger when her past catches up with her, while Sun hands herself over to the authorities. Nomi and Amanita look for a safe haven after their apartment is ransacked.
Sun is impressed with her new cellmates when she arrives at a women's correctional facility, while Nomi turns to an old hacker friend for help in tracking those seeking to lobotomize her. Will and his partner chase a lead on a missing body, and Riley returns home to her father. Meanwhile, Lito and his friends are confronted by Daniela's ex-boyfriend.
Sun endures retribution after coming to the aid of a fellow inmate, and Capheus faces severe consequences when he decides to stop working for his wealthy benefactor. As Riley and Will draw closer, Lito and Hernando learn the high cost of secrecy. Meanwhile, Nomi and Will both discover the biomedical company trying to lobotomize her.
Riley reunites with a woman from her past, who leaves her with a warning about Jonas Maliki. As a mournful Lito revisits his past with Hernando as he considers an uncertain future, Kala is interrogated about a murder she witnessed.
Wolfgang faces the criminal who attacked his friend and must rely on help from Lito to survive, prompting Lito in turn to try and rescue Daniela. While Will bonds with his father, Riley attends her father's orchestral performance in Iceland -- with a shocking finale.
When Riley falls ill, Will and Nomi plot a way to free her before the people who are hunting them learn what she is. Sun's brother confronts her with terrible news, and Wolfgang acts to protect Felix. Meanwhile, Capheus confronts a slum lord -- with bloody consequences.
Will rushes to Iceland to come to the aid of Riley -- but will need help from his friends to get inside the Biologic research facility where she is being held by Mr. Whispers. Kala bears witness to Wolfgang's final showdown with a crime boss.
