The U.S.S. Voyager pursues a rogue Maquis vessel into the Badlands, where a powerful alien sweeps both ships 70,000 light years from Earth. The "Caretaker" begins experimenting on the crew to look for a way to reproduce.
The crew defends the planet Ocampa from the Kazon, and must take a drastic step that will leave them stranded in the Delta Quadrant. With the Maquis ship destroyed, the two crews decide to join forces aboard Voyager.
Janeway and Paris investigate the remains of a long-dead civilization, where a temporal fracture sends them back in time to a few days before the accident that decimated the planet.
Voyager encounters the Phage-striken Vidiians, who harvest Neelix's lungs for their own use. The Doctor saves the Talaxian's life with holographic technology, though it may leave Neelix in restraints for the rest of his life.
Voyager investigates a space anomaly, and ends up harming a giant life-form. Janeway decides to attempt to heal the being, at great risk to the ship and crew.
Voyager finds a micro-wormhole back to the Alpha Quadrant, through which the crew makes contact with a Romulan ship. Janeway and the crew consider the possibility of transporting through the wormhole back home.
Voyager's crew encounters a planet of extremely hospitable people -- who refuse to share technology that could send the ship 40,000 light years closer to home.
After Chakotay and Tuvok return from a near-fatal encounter with an alien ship, the crew realizes that a non-corporeal alien entity is possessing their bodies in an attempt to commandeer the ship.
Torres awakens in a Vidiian laboratory to discover that she has been transformed into a full Klingon, and exposed to the Phage in the hopes of finding a cure.
An ailing scientist tracks down Neelix on board Voyager, with news that the Talaxian may be suffering from a terminal illness. Neelix struggles with the scientist's presence, since the man was responsible for mass genocide during their war with his people.
Tuvok is charged with putting a group of failing former Maquis crew members through Starfleet basic training, while Torres and the engineering crew struggle with ship-wide systems failures resulting from infected bioneural gel packs.
