After the Warehouse is destroyed the team travel across the world to find a powerful artifact capable of turning back time, putting them up against a dangerous brotherhood sworn to protect it.
When Claudia attempts to use an artifact to bring a friend back from the dead, Artie tries to intervene. Meanwhile, Pete and Myka hunt an artifact that creates angry mobs through mass hallucinations, and Artie is approached for help by Brother Adrian.
A small-town crook steals a container of artifacts and sells them to a pawn shop -- except for the tornado-generating pipe he keeps for himself -- sending the team on a scavenger hunt.
While Pete and Claudia help Hugo track down a set of ability-enhancing marbles at his nephew's prep school, Myka and Jinks are sent on their own investigation in New Orleans. Meanwhile, Brother Adrian suggests a potential way of tracking the missing Astrolabe.
Pete and Myka investigate a hockey player who is getting some supernatural help on the ice. Artie learns how extensive the thefts at the warehouse are, and Claudia is summoned to a mysterious meeting with Mrs. Frederick.
A young woman is possessed by the murderous spirit of Alice Liddell, who sets out in search of revenge. Elsewhere, Artie meets with Vanessa in the hopes of taking their relationship to the next step.
A new drug appears to be making people taller, and Pete and Myka must deal with an ambitious executive from the company responsible. Meanwhile, Artie, Jinks, and Claudia attempt to track down Brother Adrian.
While Pete and Myka investigate a group of workers who are rusting from the inside out, Jinks returns home in the hope of finding a way to end his dependence on the Metronome. Artie is forced to come clean about his past actions when he is confronted by Mrs. Frederick.
Brother Adrian sends dangerous artifacts to the team's unsuspecting family members, putting them all in danger when they hurry to help: Myka and her sister, Pete and his ex-wife, and Claudia and her brother. Meanwhile, Mrs. Frederic and Steve make a discovery at the Vatican.
The team tracks one of their own after Artie suffers a personality fracture, attempting to find the Astrolabe and annihilate the Warehouse. Meanwhile, Pete sees visions of Leena leading him to the dagger Artie fears will be used to kill him.
With the entire world threatened by the sweating sickness, Pete and Myka must rely on a professor with his own selfish agenda. Claudia and Steve enter Artie's subconscious to try and pull him out before his body dies.
Pete and Claudia go to Oregon to investigate an artifact that may have been used by a radical environmental group to bury a man alive. Meanwhile, Myka and Steve worry about Artie's emotional recovery.
An unfinished manuscript traps Pete and Myka in a 1940s pulp fiction story, in which they must locate a missing artifact. Meanwhile, Artie, Claudia, and Steve try and trap a supernatural car thief.
Pete and Myka go to Las Vegas, where they find an aging magician who has the ability to levitate people -- unintentionally resulting in their deaths. Steve and Claudia track an artifact at a horse track, and Artie meets the new owner of the B&B.
H.G. Wells calls on Pete and Myka to help find and artifact that is forcing criminals to confess to their crimes. Meanwhile, the rest of the team investigates the cause of tremors within the Warehouse.
A volcanic event inside a prison yard brings the team to Arkansas, where they join a U.S. Marshal in tracking a pair of escaped convicts. Meanwhile, Artie has a close encounter with Beethoven while preparing for Claudia's birthday party.
Pete and Myka investigate a gated community, where someone may be using multiple artifacts to take revenge on those who have wronged him. Meanwhile, Artie and Claudia go looking for a genius kid who has scrawled complex math equations on a New York wall.
Artie negotiates with a black market dealer in order to track a collection of artifacts stolen from Warehouse 12 by an infamous pirate. Jinks grows suspicious of the team's new house guest.
To find an escaped alchemist and save Claudia, Pete and Myka must reunite a pair of immortal con artists. Artie learns that something is affecting both Mrs. Frederic and the soul of the Warehouse itself.
With Mrs. Frederic fading the team goes after Paracelsus, attempting to re-bronze him before he can achieve immortality. Meanwhile, Pete presses Myka to attend to her illness, and Sutton looks for a fresh start.
